VDR is a gene which encodes for a protein which acts as a receptor vitamin D that regulates bone development and calcium absorption. A variant of the gene known as rs2228570 (FokI polymorphism) is associated with decreased bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of on- and off occupancy of the VDRE by the two components, and is influenced through chromosomal sites and binding preferences for certain hormones. Microarray studies of human cells reveal that over 100 genes have an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for information and documents related to legal, business, or proceedings that are restricted in viewing and downloading. It makes use of a central computer and an extranet that is a restricted-access Internet connection, to allow users to login at set times.
VDRs are most commonly used by investment banks and businesses involved in mergers and acquisitions. They need to be able to share information in a transparent manner with potential investors and buyers. The due diligence process may also require a huge amount of information. Life science companies also use VDRs for everything from clinical trials results to HIPAA compliance documentation.
